Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers. We are seeking a highly motivated and independent Senior Scientist with a proven track record of scientific excellence and project leadership experience in cancer biology to join our antibody-drug conjugates (ADCs) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA. Accountabilities: As a Senior Scientist, you are an essential team member focused on bringing new ADC projects into the portfolio and advancing them through all stages of pre-clinical development. You will have a direct impact on the drug discovery process as a contributor in the lab and potentially as a project team leader. You will be expected to serve as Oncology biology lead for one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable milestone progression decisions. Responsible for the delivery of key pre-clinical data that support a strong biological rationale for program progression. Working in the laboratory to develop, design, conduct, troubleshoot, and analyze in vitro experiments to assess the function of our ADCs and dissect the mechanism of action of these novel cancer therapeutics. Essential Skills/Experience: * Ph.D. in Chemical/Biochemical engineering, Chemistry, Biochemistry, Pharmaceutical Sciences or related field with a minimum of 3 years of relevant experience. * Knowledge of antibody and/or general protein sequence and structural analysis * Experience with formulation development, biophysical characterization and stability of proteins * Science oriented, highly motivated self-starter with aim to succeed * Good communication skills, strong social skills, leadership qualities, and ability to thrive in an interdisciplinary fast paced environment Desirable Skills/Experience: * Prior experience in the biopharmaceutical industry * Hands on experience with pre-clinical in vivo models of cancer * Experience in pre-clinical models of hematological cancer, and hematological cancer cell biology About AstraZeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. At AstraZeneca, we are dedicated to creating a culture of inclusion and collaboration. We believe employees benefit from being challenged and inspired at work. We are proud to be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We are at the forefront of creating new solutions that put patients at the core, powering the business to more efficiently predict, prevent and treat their conditions. We are high-reaching self-starters, proactively driving our own learning. We balance our hyper-focus and results-driven mindset with an approach that is welcoming and down-to-earth. Are you ready to follow the science? Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity, passion and determination we are paving the way to change the practice of medicine in Oncology. Apply now and be part of our mission to eliminate cancer as a cause of death! Where can I find out more? Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/ Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/ Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en Date Posted 09-Sep-2024 Closing Date 14-Sep-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.