Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

​​Position Description:

Calico seeks an experienced mechanistic neurobiologist interested in identifying and understanding the causes of age-associated neurodegeneration. Specifically, we are interested in applicants with a long-term interest in understanding the pathobiology of Parkinson’s disease, with a particular emphasis on dysregulation of organelle function, stress signaling and metabolism. The successful candidate will have demonstrated experience applying biochemical, molecular and cell biological approaches to study the physiology of brain cells, making use of innovative imaging and ‘omics technologies to answer complex questions. We are seeking a scientist that can deploy cellular perturbation systems for ascertaining causal events in neurodegeneration by integrating mechanistic findings with observations made in vivo and with hypotheses derived from human data sets. Senior/Principal Scientists at Calico are expected to be independent and function well in a highly collaborative, cross-functional research environment working closely with state-of-the art technology labs, physiology, as well as data science and machine learning groups and can lead ambitious research projects.

Position Requirements:

• Ph.D. in biochemistry, molecular and cellular biology, neuroscience, or related field and 5+ years of post-doctoral or industry experience
• Strong record of originality and productivity including impactful publications
• Ability to design complex in vitro experiments that include multimodal technologies (RNAseq, ATACseq, metabolomics, etc.)
• Proficient in quantitative analysis of complex ‘omics data sets
• Excellent communication skills
• Strong track record of working collaboratively with an interdisciplinary team to produce high quality results in a timely manner
• Must be willing to work onsite 5 days per week

The estimated base salary range for this role is $163,000 - $201,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.