Johnson and Johnson is currently seeking a n Principal Scientist, Discovery Chemistry located onsite in Spring House, PA. At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/. For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world's most pressing healthcare challenges. We know that the success of our business - and our ability to deliver meaningful solutions - depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential. At Johnson & Johnson, we all belong. The Radiochemist will be a technical expert in the discovery and development of radiolabeling chemistries to produce therapeutic radiopharmaceuticals. They will work in collaboration with team members, other departments, and external partners (C(D)MOs) to ensure the successful development of novel radioligands, enable the supply of radiolabeled compounds for preclinical experiments, and support the development of radiopharmaceutical manufacturing processes for clinical development. Primary responsibilities: * Accelerate the development of the next-generation radiopharmaceuticals by leading radiochemistry research and development efforts for discovery programs. * Develop new radiolabeling methods and formulations for discovery and preclinical stage programs. * Evaluate novel chelator and linker combinations that incorporate radioisotopes to drive optimal biophysical properties. * Work closely with discovery biology teams as well as PET radiochemistry to assist teams in the development of companion diagnostics. * Develop drug product formulations that resolve or minimize secondary radiolytic self-decomposition processes. * Develop novel analytical methods that accommodate different modalities. * Synthesize, test and supply optimized radiolabeled compounds on demand to support preclinical evaluation of novel radioligands. * Support the development of cGMP radiopharmaceutical manufacturing processes to enable clinical development activities. * Support the filing of regulatory documents (INDs, ANDAs) for the use of the novel radiopharmaceutical. * Technical transfer the radiochemistry, analytical procedures and techniques as well as proprietary methods to clinical development manufacturing operations. * Provide technical support for the development of cGMP radiopharmaceutical manufacturing processes. * Radiation safety and consulting to internal teams. * Prepare and deliver presentations for internal and external team meetings. * Author development reports, manuscripts for publication in journals, and patents.